|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
[Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats].
|
24589593 |
2014 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
We also found that the carriers of minor T allele of KCNMB1-rs11739136 had a significantly decreased risk for hypertension (TT+CT vs. CC; odds ratio=0.83; 95% confidence interval, 0.72-0.95; P value after the Bonferroni correction=0.008 x 5=0.040).
|
18496125 |
2008 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone.
|
25576871 |
2015 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone.
|
25576871 |
2015 |
|
Bacteremia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that GAS infection preferentially induces ineffective LAP to evade xenophagic killing in endothelial cells through the SLO/β1 integrin/NOX2/ROS pathway.<b>IMPORTANCE</b> Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia.
|
31575768 |
2019 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.
|
31486669 |
2020 |
|
Essential Hypertension
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The dominant model of KCNJ11 E23K and KCNMB1 E65K might be susceptible factors for essential hypertension.
|
31169684 |
2019 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The rs11739136 KCNMB1 Glu65Lys polymorphism in the beta1 subunit of the Ca2+ and voltage-dependent potassium channel has, in some studies, been reported to associate with a protective effect on diastolic hypertension.
|
18854753 |
2008 |
|
Insulin Resistance
|
0.200 |
Biomarker
|
phenotype |
RGD |
Reduction of large-conductance Ca²(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats.
|
21425425 |
2011 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.
|
16293791 |
2005 |
|
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia.
|
14522958 |
2003 |
|
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Sleep Apnea, Obstructive
|
0.010 |
Biomarker
|
disease |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Ventricular Fibrillation, Paroxysmal Familial, 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that coexpression of hbeta(1) exposes a more severe functional defect that results in a greater overlap in the relationship between channel inactivation and activation (window current) in T1620M, which is proposed to be a potential pathophysiological mechanism of IVF in vivo.
|
10618304 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
RGD |
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats.
|
18790848 |
2008 |
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon.
|
27288421 |
2016 |
|
Essential Hypertension
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genotype and allele frequency analyses revealed that the frequency of genotypes KCNJ11-rs2285676 and KCNMB1-rs11739136 was not significantly different between the EH and NT groups.
|
28962116 |
2017 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.
|
15057310 |
2004 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.
|
16155733 |
2005 |
|
Myocardial Ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.
|
16155733 |
2005 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
RGD |
Downregulation of the BK channel beta1 subunit in genetic hypertension.
|
14551242 |
2003 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Current transients associated with BK channels in human glioma cells.
|
12962281 |
2003 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |